产品货号：
Z29353
中文名称：
UIMC1抗体
英文名称：
Anti-UIMC1 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-UIMC1 Antibody (C-term) |
| 指标别名 | ubiquitin interaction motif containing 1;RAP80;X2HRIP110;UIMC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | FCM,WB |
| 基因名称 | UIMC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1. |
| 计算分子量 | 80kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin.Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites,leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin.May interact with monoubiquitinated histones H2A and H2B;the relevance of such results is however unclear in vivo.Does not bind Lys-48'-linked ubiquitin.May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. |
| Uniprot ID | Q96RL1 |
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